Baeyer-Villiger oxidation enantiodivergent

Table 9.4 Mutagenesis of CHMOAcineto toward enantiodivergent Baeyer-Villiger oxidations.

Parallel to the modification of the catalytic performance in Baeyer-Villiger oxidations, random mutagenesis was successfully applied to improve the stereoselectivity of CHMOAcineto hi cascs of essentially racemic sulfoxide formation. In addition, enantiodivergent clones with >98% ee for both antipodal products were identified (Table 9.5) [205]. However, improvement in stereoselectivity of mutant enzymes was often accompanied by increased formation of sulfone. This effect can also be utilized to resolve racemic sulfoxides. 

Scheme 2.164 Enantiodivergent microbial Baeyer-Villiger oxidation involving nonclassic resolution...

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