Baeyer camphor

An alternative method to the Baeyer-Villiger reaction is that of oxidation with formaldehyde oxide. The latter can be generated by treatment of vinyl acetate with ozone, which gives, beside the wanted products, the mixed anhydride of acetic and formic acid. If a ketone is added to the ozonide mixture, formaldehyde oxide can be trapped to yield the corresponding ozonide, which on thermal decomposition forms the lactone and (or) the corresponding olefinic carboxylic acid. The transformation of camphor (11/202) to the lactone 11/203 by this method has been achieved in 63% yield [131]. 

Calciferol, 416, 418-419 Calcium, in liquid ammonia, 56 Camphor, Baeyer-Villiger oxidation, 347... 

Enzymatic Baeyer-Villiger oxygenations are not restricted to microbial cells. It has been shown that (+)-camphor, a major constituent of the volatile oil of immature sage (Salvia officinalis L.) leaves, is converted into a water soluble metabolite via enzymatic lactonization to 1,2-campholide, followed by conversion into the fi-D-glucoside-6-O-glucose ester of the corresponding hydroxy acid[68, 69). 

Figure 5 Baeyer-Villiger transformation of (H-)-camphor by 2,5-DKCMO from Pseudomonas putida. (From Ref. 6.)...

---