B—GH interface

Each interface contains 11 or 12 hydrogen bonds or salt bridge interactions. Although the GH/GHR complex buries more surface area into its interface, it stiU contains only 12 specific interactions. Three of the IFN-7/ IFN-7RI interactions occur between mainchain atoms in the AB loop of IFN-7 and the L2 loop of IFN-7RI. In addition to the 12 receptor-cytokine interactions, seven water molecules bridge the donor and acceptor groups of IFN-7 and IFN-7RI via hydrogen bonds (Randal and Kossiakoff, 2001). Since the B-factors for the water and protein atoms in the complex are essentially the same, the water molecules are considered to be an integral part of the interface. The presence of ordered water molecules in the IFN-7/IFN-7RI interface is not likely unique, since the IL-lO/IL-lORl interface is even more polar. However, the poorer diffraction quality of IL-10 complex crystals ( 2.9A versus 2.0A) obtained at this time prevents a detailed description of the interfacial waters. The water molecules in the... 

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