B12 and Cobaloximes

The /JL-fac isomer of [Co(aeaps)2] [aeaps = 2-aminoethyl 3-aminopropyl sulfide (13)] reacts with strong base, as shown in Eq. (5), to give the alkyl cobalt(III) complex (14) which has been characterized as the dithionate salt and its crystal 

Structure determined. Spectrophotometry shows that the alkyl-cobalt(III) complex is only one of several species present at equilibrium in 1 M sodium hydroxide solution. 

It is claimed that multiple regression analyses, involving Taft s polar substituent constant or and Dubois steric parameter E, can satisfactorily account for the properties of alkyl cobaloximes (R = alkyl) and alkyl cobalamines in terms 

Substitution Reactions of Inert-Metal Complexes— Coordination Numbers 6 and Above  

8 Inert-Metal Complexes Other Inert Centers 

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