Azurocidin

Almeida, R. P., Melchior, M., Campanelli, D., Nathan, C., Gabay, J. E. (1991). Complementary DNA sequence of human neutrophil azurocidin, an antibiotic with extensive homology to serine proteases. Biochem. Biophys. Res. Commun. 177, 688-95. 

Chertov O, Michiel DF, Xu L, Wang JM, Tani K, Murphy WJ, Longo DL, Taub DD, Oppenheim JJ Identification of defensin-1, defensin-2, and CAP37/azurocidin asT-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils. J Biol Chem 1996 271 2935. 

Chertov O, Ueda H, Xu LL, Tani K, Murphy WJ, Wang JM, Howard OM, Sayers TJ, Oppenheim JJ Identification of human neutrophil-derived cathepsin G and azurocidin/CAP37 as chemoattractants for mononuclear cells and neutrophils. J Exp Med 1997 186 739-747. 

This is a 29-kDa protein that has NH 2-terminal sequence homology with elastase and cathepsin G. However, it contains glycine and not serine at the predicted catalytic site, and so lacks protease and peptidase activity. Purified azurocidin kills a range of organisms (e.g. E. coli, S.faecalis, and C. albicans) in vitro. It functions optimally at pH 5.5 and in conditions of low ionic strength. 

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