Clozapine Azoles

Information appears to be limited to this study and the three case reports, but clozapine has not been found to interact with other potent inhibitors of CYP3A4, see Clozapine + Azoles , p.745. An interaction seems unlikely, although the case reports do suggest that rarely some patients may be affected. Bear this interaction in mind in the case of an unexpected response to treatment. Note that infection may be a sign of clozapine-induced agranulocytosis. 

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