Aziridines isomerisation

In 2007, Frauenrath and Flock described the double bond isomerisation of 5-methyl-4//-l,3-dioxin performed upon catalysis with [Nil2(i ,i )-Me-DU-PHOS], which afforded the corresponding chiral dioxins in excellent enantioselectivities of up to 95% ee, along with good yields (Scheme 10.18). These products were further aziridinated and then ring-opened to lead to chiral 4-methyl-l,3-oxazolidine-4-carbaldehydes with 73% de. 

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