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Aziridine adenylates

Aziridine adenylates 368 (Scheme 75) take part in MTase dependent DNA alkylations [261-263], where the aziridines are believed to undergo quar-ternization of the 5 -amine followed by MTase binding, delivery to the site of methylation, and subsequent aziridinium ring opening with concomitant substrate alkylation. [Pg.70]

Scheme 75 Structure of 5 -aziridine adenylates 368 as MTase-dependent DNA-modifying agents [264]... Scheme 75 Structure of 5 -aziridine adenylates 368 as MTase-dependent DNA-modifying agents [264]...
See other pages where Aziridine adenylates is mentioned: [Pg.427]    [Pg.222]    [Pg.73]   
See also in sourсe #XX -- [ Pg.103 ]



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