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2-Azido-3-methoxypyrazine

The major and recently used preparative routes to azidopyrazines have been covered already by azidolysis of halogenopyrazines (Sections 4.2.6 and 4.4) and by treatment of hydrazinopyrazines with nitrous acid (Section 7.4). In addition, direct C-azidation of pyrazines has been used for example, the lithio intermediate (225), generated in THF by treatment of 2-methoxypyrazine (224) with lithium 2,2,6,6-tetramethylpiperidine, gave 2-azido-3-methoxypyrazine (226) (87%) on subsequent treatment with p-toluenesulfonyl azide.232... [Pg.294]

Azido-3-methoxypyrazine (231) gave 2-methoxy-3-triphenylphosphoranylide-neaminopyrazine (232) (PPh3, PhH, reflux, 65 h 90%).232... [Pg.295]

Azido-6-methoxypyrazine (242) gave 2,7-dimethoxy-l,3,5-triazepine (241) (hv, MeO, MeOH—dioxane, 25 min >40%) or 2-diethylamino-7-methoxy-1,3,5-triazepine (243) (hv, Et2NH, MeOH—dioxane, 25 min >40%) it appears that the substrate must bear an electron-donating group for this reaction to occur.171... [Pg.297]

See other pages where 2-Azido-3-methoxypyrazine is mentioned: [Pg.367]    [Pg.367]   
See also in sourсe #XX -- [ Pg.294 ]

See also in sourсe #XX -- [ Pg.294 ]



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