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Azido groups amine protection

Amino group protection The reagent reacts with amines to form carbamates. Release of the amines is accomplished by reduction of the azido group with dithiothreitol. The 4-aminobenzyl carbamates thus generated undergo spontaneous fragmentation. [Pg.16]

As shown in Scheme 8.2, template 4 allowed preparation of carbamates at the C-3 position by selective removal of the levulinate protecting group followed by reaction with isocyanates. The three templates 5, 6, and 7 supported introduction of diversity at both the C-3 and C-2 positions by removal of the base-labile protecting group at C-2 and subsequent derivatizations to form antides (Scheme 8.3). Reduction of the C-3 azido group to a primary amine and reaction with isocyanates... [Pg.193]

See other pages where Azido groups amine protection is mentioned: [Pg.646]    [Pg.646]    [Pg.200]    [Pg.46]    [Pg.283]    [Pg.200]    [Pg.76]    [Pg.347]    [Pg.339]    [Pg.82]    [Pg.1956]    [Pg.1006]    [Pg.2128]    [Pg.257]    [Pg.361]    [Pg.57]    [Pg.132]    [Pg.132]    [Pg.165]    [Pg.167]    [Pg.138]    [Pg.42]    [Pg.41]    [Pg.268]    [Pg.101]    [Pg.267]    [Pg.314]    [Pg.193]    [Pg.595]    [Pg.314]    [Pg.171]    [Pg.173]    [Pg.201]    [Pg.65]    [Pg.472]    [Pg.543]    [Pg.128]    [Pg.311]    [Pg.249]    [Pg.259]    [Pg.281]    [Pg.53]    [Pg.166]    [Pg.272]    [Pg.99]   
See also in sourсe #XX -- [ Pg.6 , Pg.646 ]

See also in sourсe #XX -- [ Pg.646 ]

See also in sourсe #XX -- [ Pg.6 , Pg.646 ]

See also in sourсe #XX -- [ Pg.646 ]



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Amine groups

Amines azido

Azido group

Protective groups amines

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