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Azeto benzothiazepines

As is the case for azirino-1,5-benzothiazepines, for azeto-1,5-benzothia-zepines the only known example concerns the fusion on the d edge of the seven-membered ring. [Pg.64]

The tautomers of 3-ethoxycarbonyl-2-phenyl-4,l-benzothiazepine and its 2-(4-methylphenyl) and 2-(4-chlorophenyl) derivatives can be separated in the form of single crystals suitable for X-ray diffraction. The single crystals 32a—e and 33a—e were prepared from azeto-3,l-benzothiazines 31a—e by treatment with sodium ethoxide in dry ethanol at room temperature. The reaction proceeds rapidly in 10 min the starting material had disappeared. In each case, two products 32a—e and 33a—e were obtained. After column chromatography and evaporation of the eluent, trituration with n-hexane furnished separate desmotropes 32a—e and 33a—e as crystaUine compounds in relatively good yield (Scheme 24). The desmotropes were found to be... [Pg.226]


See other pages where Azeto benzothiazepines is mentioned: [Pg.64]    [Pg.64]    [Pg.64]    [Pg.476]    [Pg.531]   
See also in sourсe #XX -- [ Pg.63 , Pg.64 ]

See also in sourсe #XX -- [ Pg.63 , Pg.64 ]




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1.5- Benzothiazepine

Benzothiazepines

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