Azepines, Beckmann rearrangement synthesis

The Beckmann rearrangement has been a popular method for the synthesis of azepine systems based upon caprolactam. A recent example is the synthesis of 7,8-... 

The present chapter is not intended to be a catalogue of all aspects of azepine chemistry which have been published since CHEC-I. Thus, for example, many established areas such as the Beckmann and Schmidt reactions for the preparation of reduced azepines are discussed only in respect to newer developments. The Beckmann rearrangement has been reviewed <870R(35)i>. The emphasis is to take forward the knowledge of azepine chemistry, to describe new chemistry and to develop earlier aspects which were just emerging when CHEC-I was being prepared. Such aspects include the synthesis and properties of azepine-3(2//) Ones, the formation of bicyclic and tricyclic azepines by the cyclization of diene-conjugated nitrile ylides and those results since 1984, theoretical and experimental, on the mechanism and synthetic applications of aryl azide chemistry. 

---