Azelastine, pharmacokinetics

McTavish D, Sorkin EM Azelastine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential. Drugs 1989 38 778-800. 

Fexofenadine levels are raised by both azithromycin and erythromycin but because this does not result in adverse cardiac effects concurrent use is considered safe. Azelastine, cetirizine (and therefore probably its isomer levocetirizine) desloratadine and levocabastine seem to be free from clinically significant pharmacokinetic interactions, and have no cardiac effects, and so may therefore provide suitable alternatives if a non-sedating antihistamine is needed in a patient taking macrolides. 

Sale M, Lyness W, Perhach J, Woosley R, Rosenberg A. Lack of effect of coadministration of erythromycin (ERY) with azelastine (AZ) on pharmacokinetics (PK) or... 

Azelastine, cetirizine, ketotifen, mequitazine, mizolastine, pemirolast, repirinasit, and terfenadine do not appear to alter the pharmacokinetics of theophylline. 

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See also in sourсe #XX -- [ ]

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