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Azelaic acid monomethyl ester

The tetraacetylenic compound (-)-minquartynoic acid was synthesized in the laboratory of B.W. Gung from commercially available azelaic acid monomethyl ester using a one-pot three-component Cadiot-Chodkiewitz reaction as the key step. This natural product shows strong anti-cancer and anti-HIV activity. One of the alkyne components was prepared using the modified Seyferth-Gilbert homologation. [Pg.403]

Acetonitrile, ether, and azelaic acid dimethyl ester added with vigorous stirring and ice-cooling to a soln. of KOH in methanol (MeOHiMeCNiEt O 12 40 40), left for 50 h at 0 , the precipitated K-monoester removed and treated with dil. HCl - azelaic acid monomethyl ester. Y 78%. F.e.s. S.I. Zavyalov, N.E. Kravchenko, Izv. Akad. Nauk SSSR Ser. Khim. 1988, No. 7, 1696. [Pg.17]

Half ester of adipic acid Monomethyl azelaic acid 2-Methyl naphthalene Naphthalene Furan Toluene Benzene... [Pg.760]

See other pages where Azelaic acid monomethyl ester is mentioned: [Pg.108]    [Pg.87]    [Pg.108]    [Pg.87]    [Pg.217]    [Pg.496]    [Pg.131]   
See also in sourсe #XX -- [ Pg.217 ]

See also in sourсe #XX -- [ Pg.217 ]



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