Azafluoranthene alkaloids

Cava MP, Buck KT, daRocha AI (1972) Azafluoranthene alkaloids. A new structural type. J Am Chem Soc 94 5931... 

Microwave-assisted direct aiylation reactions were successfully employed in the synthesis of azafluoranthene alkaloids. Ponnala and Harding (2013) reported that direct aiylation reactions on a diverse set of phenyltetrahydroisoquinolines produced the indeno[l,2,3-ij]isoquinoline nucleus, required towards a high-yielding azafluoranthene synthesis. The method was used as a key step in the efficient preparation of the natural products rufescine and triclisine. This synthetic approach may be generally applicable to the preparation of natural and un-natural azafluoranthene alkaloids as well as azafluoranthene-like isoquinoline alkaloids. 

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