Azabicyclo nonanes Mannich reaction

The data on the synthesis of azabicyclo[3.3.1]nonanes fused with azoles have recently been published [102-104]. The first step of the reaction is the formation of hydride adducts 125 by action of NaBHa (Scheme 61). These adducts undergo the Mannich condensation with formaldehyde and alkyl amines to give 3-R-l,5-dinitroa-zabicyclo[3.3.1]nonanes 126, fused with azole fragments across the C(7)-C(8) bond. 

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