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Aza-Robinson annulation

To set the stage for the crucial aza-Robinson annulation, a reaction in which the nucleophilic character of the newly introduced thiolactam function is expected to play an important role, it is necessary to manipulate the methyl propionate side chain in 19. To this end, alkaline hydrolysis of the methyl ester in 19, followed by treatment of the resulting carboxylic acid with isobutyl chlorofor-mate, provides a mixed anhydride. The latter substance is a reactive acylating agent that combines smoothly with diazomethane to give diazo ketone 12 (77 % overall yield from 19). [Pg.475]

Scheme 14.25 Bradshaw and Bonjoch s synthesis of lycoposerramine Z (170) via domino Robinson annulation/aza-Michael addition. Scheme 14.25 Bradshaw and Bonjoch s synthesis of lycoposerramine Z (170) via domino Robinson annulation/aza-Michael addition.

See other pages where Aza-Robinson annulation is mentioned: [Pg.474]    [Pg.478]    [Pg.483]    [Pg.789]    [Pg.87]    [Pg.2405]    [Pg.392]    [Pg.102]    [Pg.474]    [Pg.478]    [Pg.483]    [Pg.789]    [Pg.87]    [Pg.2405]    [Pg.392]    [Pg.102]    [Pg.544]   
See also in sourсe #XX -- [ Pg.392 , Pg.393 ]




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