Aza-7-oxa-isotwistanes Pathway

Entry to the 2-aza-7-oxa-isotwistane system was successful by olefin amination of the bicyclic amine 201 with mercuric acetate in dimethyl sulfoxide. The lO -acetoxy- 

Olefin amination of the bicyclic unsaturated secondary amine 204 with mercuric acetate in dimethyl sulfoxide yielded up to 85% of the 10 -acetoxy-2-aza-7-thia- 

Cyclization of the bicyclic bromo-amine 208 in 1,2-dichloroethane in the presence of solid N32C03 yielded over 90% of the lO -bromo-isotwistane 209. 

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