Aza-Myers-Saito reaction

This reaction has been extended to azaenyne-allene cyclization, the so-called aza-Myers-Saito cyclization. ... 

An aza-variant of the cycloaromatization of propargyl azaeneynes, such as 50, via azaenyne-allenes 51, has been reported by Kerwin et al. The aza-Myers-Saito cyclization provides a,5-didehydro-3-picoline diradical 52, which affords either polar or radical-based trapping products 53 and 54, depending on the reaction solvent. The facility of the aza-Myers-Saito cyclization relative to the parent Myers-Saito cyclization was predicted based on DFT calculations these results also indicate that the corresponding C2-C6 (aza-Schmittel) cyclization, although disfavored in the case of 51, is... 

Thermal reaction of aza-enyne-allenes 3.956a and 3.956b [18,420a,b] follow a stepwise aza-Myers-Saito cyclization mechanism via diradical... 

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