Catalysts aza-adamantane

Chiral 2-azadamantane-N-oxyls can also be used for kinetic resolution of secondary alcohols via asymmetric oxidation [131]. S-Factors of up to 82.2 were achieved for a range of cyclic and acyclic secondary alcohols using aza-adamantane catalyst 44 (Scheme 19.22). 

Scheme 19.22 Kinetic resolution of secondary alcohols using aza-adamantane catalyst 44.

While nitroxyl radicals, e.g., (2,2,6,6-tetramethylpiperidin-l-yl)oxyl (TEMPO) (2014COR459) and 2-aza-adamantane-Al-oxyl (AZADO) (2006JA8412), have been used extensively as catalysts in the oxidation of alcohols, there have been no reports of analogous uses for hydrazyls and... 

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