Golgi apparatus axonal transport

In contrast to the small transmitter molecules, the neuropeptides are synthesized in the rough endoplasmic reticulum of the neuronal perikarya. They are enclosed in vesicles in the Golgi apparatus. The vesicles travel down to the terminals by axonal transport. 

Hammerschlag, R., Stone, G. C., Bolen, F. A., Lindsey, J. D. and Ellisman, M. H. Evidence that all newly synthesized proteins destined for fast axonal transport pass through the Golgi apparatus. J. Cell Biol. 93 568-575,1982. 

Other neurotransmitters are larger peptides, such as the enkephalins. These peptide neurotransmitters are synthesized in the cell body of the neuron, usually as part of larger polypeptides from which they are subsequently cleaved. Following synthesis, they are incorporated into secretory granules that bud off from the Golgi apparatus and are then transported down the axon to the terminals. 

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