Axinyssa aplysinoides

Isothiocyanatocubebane (128) and 10-isothiocyanatoguaia-6-ene (129) were isolated from a Palau sponge, Axinyssa aplysinoides, which is rich in isocyano-related sesquiterpenoids [44, 49]. The former (128) is apparently related to the amorphanes (Sect. 4.1.3) and the latter (129) to the aromaden-dranes [Sect. 4.1.5]. 

Metab. of the Palauan sponge Axinyssa aplysinoides. Highly hygroscopic solid (as chloride). CAS No. refers to chloride. 

Boneratamides A-C have a sesquiterpenic moiely similar to that of axisonitrile-3 asscKiated vrith an amide bond to an a-amino acid, which may derive from proUne. These three original compoimds were isolated as their methyl esters from the species Axinyssa aplysinoides harvested in Indonesia (Latondu Island, Taka Bonerate). They may be related to exigmin (see above). Boneratamides may have an antifouling action (Williams et al, 2004b). 

Halipanicine (R = NCS) Halichondria panicea Nakamura a/., 1991 R = NC, NHCHO Axinyssa aplysinoides Compagnone and Faulkner, 1995... 

Williams, D.E., Patrick, B.O., Tahir, A., Van Soest, R., Roberge, M and Andersen, R.J. (2004b) Boneratamides A-C, new sesquiterpenoids isolated from the marine sponge Axinyssa aplysinoides. J. Nat. Prod., 67.1752-1754. 

Bensemhoun, J., Bombarda, I., Aknin, M., Vacelet, J., and Gaydou, E.M. (2008a) 7-Amrno-7,8-dihydro-a-bisabolene derivative from the marine sponge Axinyssa aplysinoides. Biochem. Syst. Ecol., 36, 326-328. 

Sorek, H., Zelikoff, A.L., Benayahu, Y, and Kashman, Y. (2008) Axiplyns A-E, new sesquiterpene isothiocyanates from the marine sponge Axinyssa aplysinoides. Tetrahedron Lett., 49, 2200-2203. 

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