Awake, coming

You want to know why I steal that money Well, a week ago poor mother she is so very sick. They tell me she cannot live many days but I think if only I have money I can save her yet. I can have doctors to see her, big doctors who will go to sick people only for very much money. I can buy her food and medicine and perhaps send her away to some place where the sun will shine for her, where she can breathe God s pure air. Why even strong people can scarce live in a place like this where the sunshine never come, where it is cold and damp all the time. How can the poor little mother hope to grow well again in such a place, without good food, often without a fire, the air not fit for anyone to breathe. I think of it all the time. I lie awake at night and think of it, it is before me all day at my work. Money, money, if only I have a little money, I can save my mother yet. Then the chance come, the money is there before me. I look at it, I take it. That is all. 

In the Koran (18 18), the Seven Sleepers also have a dog with them in the cave Thou wouldst have deemed them awake, whilst they were asleep, and we turned them on their right and on their left sides. Their dog stretched forth his two fore-legs on the threshold. If thou hadst come up on to them, thou wouldst have certainly turned back from them in flight, and wouldst certainly have been filled with terror of them. ... 

Many people drink coffee to reduce drowsiness. How does caffeine achieve this effect in the brain The answer begins with a consideration of the function of the acetylcholine neurons that control your ability to pay attention. Adenosine negatively controls the activity of these neurons, meaning that when adenosine binds to its receptor on acetylcholine neurons, their activity slows. The production and release of adenosine in your brain is linked to metabolic activity while you are awake. Therefore, the concentration of adenosine in the neighborhood of acetylcholine neurons increases constantly while your brain is active during the day. As the levels of adenosine increase, they steadily inhibit your acetylcholine neurons, your brain s activity gradually slows, and you begin to feel drowsy and ultimately fall asleep. Caffeine comes to the rescue because it, like theophylline... 

Adenosine is ubiquitous in the brain. Every cell can release it and does so rather continually while you are awake. It builds in concentration and slowly inhibits the activity of nearby neurons. Of particular concern is the inhibition of the attentioncontrolling acetylcholine neurons that project to the cortex. We need and want those neurons to be active so we consume drinks containing caffeine, a drug that quickly enters the brain and blocks the action of adenosine and releases acetylcholine neurons from the tyranny of inactivation once again, coffee comes to the rescue. 

I guess I had it coming. She wasn t contradicted. I want to live on my own anyway, I feel like I m in the way here. Slip sat up, traffic kept fishing. But it s not like I ever reneged on bills or ripped anyone off or any bullshit like that. Or kept people awake all night. And Christ I sure did my fair share of cleaning. You know how long it takes to vacuum and mop this place ... 

EXTENSIONS AND COMMENTARY There is a thread of disconnection and of inconsistent reference that pervades most of the reports that I have received concerning the use of DOPR. The word that comes to mind is hypnogogic. There is a drifting into that place that lies between a not-quite-awake and a not-quite-asleep state seems to characterize this compound. There is no question but that it is very potent, and that it is very long-lived. But there is a nagging suggestion of the out-of-body, out-of-center character that is the hallmark of the anesthetic and delusional drugs such as scopolamine or ketamine. With them, the psychedelic effects become clouded with touches of amnesia. 

The chemical shift sum publication, which, after almost 35 years, has only 20 citations, is good illustration of a Sleeping Beauty that eventually will be awaked by a prince kissing her (if he comes), a work worthy of greater attention but apparently overlooked by most researchers in the NMR area. It also illustrates that there are Sleeping Beauties that need to be kissed more than once to be awakened Skeptics may raise the question of whether this Beauty is worth kissing, whether it is worth awakening After all, the NMR chemical shift sum is an artificial construction, perhaps just a curiosity. So why should it be of interest to other scientists ... 

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