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Avermectins Diels-Alder reaction

Danishefsky and coworkers have synthesized the algylcon of avermectin based on a hetero Diels-Alder reaction between trimethylsilyloxy diene (8) and chiral aldehyde (175 Scheme 49). The pyrone must come from an anti Cram-Felkin addition, so MgBr2 is used as the catalyst in this reaction. The cycloaddition reaction gives the expected product (176) and the CF diastereomer in a ratio of 3 1. The target compound (178) is obtained after a series of reactions outlined in Scheme 49. - ... [Pg.701]

See other pages where Avermectins Diels-Alder reaction is mentioned: [Pg.35]    [Pg.268]    [Pg.83]   
See also in sourсe #XX -- [ Pg.2 , Pg.701 ]

See also in sourсe #XX -- [ Pg.2 , Pg.701 ]



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Avermectin

Avermectin Diels-Alder reaction

Avermectin Diels-Alder reaction

Avermectins

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