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Avermectin evaluation

The microorganism was classified as a new species of actinomycete. Streptomyces avermitilis. Its anthelmintic activity was shown to reside in 8 closely related macrocyclic lactones, named avermectins, which were also found to possess activity against free-living and parasitic arthropods. One of the natural components, avermectin is now being evaluated as a pesticide for the control of mites of citrus and cotton crops and control of the Red Imported Fire Ant. A chemical derivative, 22,23-dihydroavermectin or ivermectin, has been developed as an antiparasitic agent. It is being marketed for use in cattle, horses and sheep and is expected to become available for swine and dogs. [Pg.5]

In comparison, for the genera Otodectes and Chorioptes, with the exception of avermectins, no natural compound has been evaluated. [Pg.417]

The avermectin molecule presents a complex chemical framework in which a large variety of structural modifications are possible [53-66]. However, the available data on SAR in avermectins indicate that molecular variations at positions 5,13,22,23 and 26 appear to be detrimental to antiparasitic response. Accordingly, a variety of structural analogues of avermectins have been synthesized and evaluated for their biological activity. The SAR which has emerged out of this study, may be summarised as follows ... [Pg.79]

A Pfizer group evaluated a wide range of avermectin derivatives for flea activity in an in vitro feeding screen using the cat flea Ctenocephalides felis, which... [Pg.160]

We had been following the development the avermectins for several years. However, being without fermentation capabilities, we evaluated the area only in terms that might point toward a synthetic product (. We were particularly interested in the milbemycins as potential insecticides. [Pg.437]


See other pages where Avermectin evaluation is mentioned: [Pg.11]    [Pg.12]    [Pg.13]    [Pg.13]    [Pg.411]    [Pg.126]    [Pg.105]    [Pg.73]    [Pg.97]    [Pg.274]    [Pg.139]    [Pg.534]    [Pg.463]   
See also in sourсe #XX -- [ Pg.343 ]




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