Average plasma concentration at steady state extravascular route

5 Average plasma concentration at steady state extravascular route 

By applying the steady-state function and by substituting / for the intercept defined above, we obtain  

The average plasma concentration of a drug at steady state for extravascularly administered dose can be calculated from  

Equation 12.18 permits determination of minimum plasma concentration (i.e. trough plasma concentration) for a drug administered 

It is clear from Eq. 12.19 that the average plasma concentration, (Cp), is dependent on the size of the dose administered Xq, the fraction of the administered dose reaching general circulation or absorbed F) and the dosing interval (r). The dose is administered as a single dose every t time units or is subdivided and administered at 

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