Average free drug concentration

Changes in average total and free drug concentrations at steady state for an intravenously administered drug... 

The appropriate equation (see also Eq. 11.17 and Eq. 12.19) for average total (bound plus free) plasma drug concentration at steady state is ... 

Table 16.5 The effect of a change in free fraction on average total and free plasma for intravenous administration of the drugs in Table 16.4 drug concentrations at steady state ...

Since the factor u is not present in any of the four equations in Table 16.11, we expect no change in average steady-state free or total drug concentrations in response to a change in tissue binding. This is true irrespective of the mode of administration of drug ... 

How can we control the synthesis of drug carriers to govern the above features It has already been stated that the majority of water-soluble polymers are prepared by free-radical polymerization the mechanism of which is well-known. On the whole, the average molecular weight can be controlled relatively easily by the initiator concentration in the polymerization mixture, the polymerization temperature and conversion. In addition, the molecular weight distribution can be controlled to obtain a narrower range. If necessary, it is adjusted by fractional precipitation. 

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