Auditory hallucinations, in schizophrenia

Extension of this specificity principle to the clinical domain has resulted in the availability of increasingly well-aimed chemical bullets. If we wanted to block just one of the many serotonin receptors to see what would happen, we could probably do it But if we wanted to elevate mood in depression—or obsessive-compulsive disorder—would we expect the best result if we blocked just that one receptor And if we wanted to discourage auditory hallucinations in schizophrenia, would we want our drug to target only D2 dopamine receptors, even if we knew that the antipsychotic action of drugs correlated well with a drug s affinity for those receptors ... 

Levitan C, Ward PB, Catts SV. 1999. Superior temporal gyral volumes and laterality correlates of auditory hallucinations in schizophrenia. Biol Psych 46 955-962. 

McGuire PK, Shah GM, Murray RM. 1993. Increased blood flow in Broca s area during auditory hallucinations in schizophrenia. Lancet 342(8873) 703-706. 

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See also in sourсe #XX -- [ , ]

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