ATPases substrate-binding domain

Fig. 1. Domain structure of the Hsp70 and Hsp70-related protein families. Schematic representation of the ATPase domain ( 385 residues, dark gray), a small linker, and the substrate-binding domain, which is subdivided into the /3-sheet ( 150 residues, light gray) and the a-helical subdomains ( 100 residues, gradient). The white boxes in the HspllO and Hspl70 families represent insertions of unknown function.

A. M. Roseman, S. Chen, H. White, K. Braig and H. R. Saibil, The chaperonin ATPase cycle mechanism of allosteric switching and movements of substrate-binding domains in GroEL, Cell, 1996,87,241-251. 

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