ATP conformational changes

Most mechanisms for the (Ca2+, Mg2+)-ATPase are modifications of the proposal of deMeis et a/.128 An example is shown in Figure 9. The ATPase can utilize CaATP and MgATP as substrates.147 Two moles of Ca2+ are bound per mole of the phosphorylation site with high affinity, followed by phosphorylation of the enzyme by ATP. Conformational changes in the phosphoprotein lead to the calcium sites being accessible to the intravesicular space, with decrease in their affinity for... 

Fast transport in cells requires vehicles (the organelles or vesicles), motors and fuel. The motors can be divided into two families, the cytoplasmic dyneins and the kinesins (Fig. 5-35). Each uses ATP as a fuel, the energy being provided by its hydrolysis to ADP and P . The motors can sense the polarity of the microtubules dyneins drive toward the minus end, while most kinesins drive toward the plus end. Movement is generated by cyclic hydrolysis of ATP, conformational changes, and the reversible attachment to microtubules. 

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See also in sourсe #XX -- [ , ]

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