Metoclopramide Atovaquone

Atovaquone (Mepron) [Antiprotozoal] Uses Rx prevention PCP Action 4- nucleic acid ATP synth Dose Rx 750 mg PO bid for 21 d Prevention 1500 mg PO once/d (w/ meals) Caution [C, ] Disp Susp SE FevCT, HA, anxiety, insomnia, rash, N/V Interactions X Effects W/ metoclopramide, rifabutin, rifampin, tetracycline EMS None OD Sxs unknown but may cause a rash symptomatic and supportive... 

Atovaquone is poorly absorbed from the gastrointestinal tract, but absorption is increased with a fatty meal. Excretion of the drug, mostly unchanged, occurs in the feces. The elimination half-life is 2 to 3 days. Low plasma levels persist for several weeks. Concurrent administration of metoclopramide, tetracycline, or rifampin reduces atovaquone plasma levels by 40 to 50%. 

METOCLOPRAMIDE ANTIMALARIALS -ATOVAQUONE 1 atovaquone levels Uncertain Avoid consider an alternative antiemetic... 

Preliminary evidence suggested that, of a number of drugs given with atovaquone in clinical trials, only metoclopramide caused any marked change (decreases) in the atovaquone serum levels. Until more is known, it may be prudent to monitor efficacy if metoclopramide is used with atovaquone. 

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