Atom transfer radical addition deactivator concentration

Figure 3 shows the simple case of a clock reaction competing with hydrogen atom transfer from tin hydride. If one wished to determine, for example, the rate of addition of a primary alkyl radical to an activated alkene such as an acrylate, then the reaction could be run at low concentrations of tin hydride such that both the radical clock and its rearrangement product reacted predominantly with the alkene. The products of the acrylate addition reaction are deactivated with respect to addition to another acrylate molecule, and one could control concentrations such that these adducts reacted primarily with the tin hydride (Scheme 3). In this case, then, one would analyze for the acrylate addition products of the unrearranged and rearranged radicals.

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