Asymmetrization of Prochiral Compounds

For a recent review on enzymatic asymmetrization of prochiral and meso compounds, see Schoffers et al. [113]. Enzymatic asymmetrization of prochiral compounds was discussed by Ogston in 1948 [114]. He then rationalized the enzyme s ability to discriminate between enantiotopic groups on a prostereogenic substrate molecule based on the three-point combination model. 

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