Asymmetric synthesis via

There have been several reviews of asymmetric synthesis via chiral organoboranes (6,8,378,382,467—472). Asymmetric induction in the hydroboration reaction may result from the chiraHty present in the olefin (asymmetric substrate), in the reagent (asymmetric hydroboration), or in the catalyst (catalytic asymmetric hydroboration). 

Asymmetric substrate, 13 664-665 Asymmetric synthesis, via chiral organoboranes, 13 664-671 ATI receptor, 5 158 Atacama Desert, sodium nitrate in, 22 844-845 Atacamite, 7 769... 

Bartlett PA, Johnson WS, Elliott JD (1983) Asymmetric synthesis via acetal templates. 3. On the stereochemistry observed in the cyclization of chiral acetals of polyolefinic aldehydes formation of optically active homoallylic alcohols. J Am Chem Soc 105 2088-2089... 

Systematic studies of topochemical reactions of organic solids have led to the possibility of asymmetric synthesis via reactions in chiral crystals. (A chiral crystal is one whose symmetry elements do not interrelate enantiomers.) (Green et al, 1979 Addadi et al, 1980). This essentially involves two steps (i) synthesis of achiral molecules that crystallize in chiral structures with suitable packing and orientation of reactive groups and (ii) performing a topochemical reaction such that chirality of crystals is transferred to products. The first step is essentially a part of the more general problem of crystal engineering. An example of such a system where almost quantitative asymmetric induction is achieved is the family of unsymmetrically substituted dienes ... 

For a review of asymmetric synthesis via chiral oxazolines, see Lutomski Meyers, in Morrison. Ref. 1467, pp. 213-274. 

J. D. Elliott, V. M. F. Choi, and W. S. Johnson, Asymmetric synthesis via acetal templates. 5. Reactions with cyanotrimethylsilane. Enantioselective preparation of cyanohydrins and derivatives, J. Org. Chem. 78 2294 (1983). 

Reviews on stoichiometric asymmetric syntheses M. M. Midland, Reductions with Chiral Boron Reagents, in J. D. Morrison, ed., Asymmetric Synthesis, Vol. 2, Chap. 2, Academic Press, New York, 1983 E. R. Grandbois, S. I. Howard, and J. D. Morrison, Reductions with Chiral Modifications of Lithium Aluminum Hydride, in J. D. Morrison, ed.. Asymmetric Synthesis, Vol. 2, Chap. 3, Academic Press, New York, 1983 Y. Inouye, J. Oda, and N. Baba, Reductions with Chiral Dihydropyridine Reagents, in J. D. Morrison, ed., Asymmetric Synthesis, Vol. 2, Chap. 4, Academic Press, New York, 1983 T. Oishi and T. Nakata, Acc. Chem. Res., 17, 338 (1984) G. Solladie, Addition of Chiral Nucleophiles to Aldehydes and Ketones, in J. D. Morrison, ed., Asymmetric Synthesis, Vol. 2, Chap. 6, Academic Press, New York, 1983 D. A. Evans, Stereoselective Alkylation Reactions of Chiral Metal Enolates, in J. D. Morrison, ed., Asymmetric Synthesis, Vol. 3, Chap. 1, Academic Press, New York, 1984. C. H. Heathcock, The Aldol Addition Reaction, in J. D. Morrison, ed., Asymmetric Synthesis, Vol. 3, Chap. 2, Academic Press, New York, 1984 K. A. Lutomski and A. I. Meyers, Asymmetric Synthesis via Chiral Oxazolines, in J. D. Morrison, ed., Asymmetric Synthesis, Vol. 3, Chap. 

Scheme 11 Asymmetric synthesis via Norrish type 2 reaction.

Scheme 12 Asymmetric synthesis via 8-hydrogen abstraction by carbonyl group.

Scheme 19 Asymmetric synthesis via hydrogen abstraction by the alkenyl carbon atom.

Scheme 34 Absolute asymmetric synthesis via nucleophilic reaction using chiral crystals.

In this chapter we show that the chirality of a ketone and some a-amino acid esters can, however, be preserved in their enolate forms, and asymmetric synthesis via the strategy shown in Scheme 3.2 becomes possible. In these reactions the chirality of the starting material appears to be memorized in the enolate intermediates, so we call this type of asymmetric transformation memory of chirality. The design, development, and rationale of the memory of chirality are described.1... 

Asymmetric synthesis via enolate intermediates has been extensively studied. Asymmetric induction can be divided into five main categories (1) a chiral auxiliary covalently linked to an enolate moiety,2,3 (2) a chiral ligand of a countercation of an enolate,4-6 (3) a chiral electrophile,7,8 (4) a chiral Lewis acid,9,10 and (5) a chiral phase-transfer catalyst.11,12 Rather than reviewing these examples, we introduce here the principle of asymmetric induction for... 

Asymmetric Synthesis via Norephedrine-Derived 2-Alkenyloxazolidines. Scolastico, C. Pure. Appl. Chem. 1988, 60, 1689. 

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