Asymmetric Synthesis of Anticancer P Lactam

The anticancer activity of our racemic (3-lactams has prompted us to devise method for the preparation of the optically active analogues. It is known that an optically active isomer of a racemic compound has better and much selective biological 

Cycloaddition of the acid 62 with imine 29a was performed using imine in the presence of iV-methyl-2-chloropyridiniumiodide (53) and triethylamine. NMR analyses of the crude reaction mixture showed the presence of two diasteromeric trans p-lactams 63 and 64 in 60 40 ratios. The diaseteromeric O-glycosides after 

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