Asymmetric reactions alkyllithium preparation

Asymmetric synthesis of alcohols. This ligand is elfective for asymmetric addition of an alkyllithium to an aldehyde. In more recent work it has been found that the lithium anion (2) of 1, prepared with n-butyllithium, is particularly eifective for asymmetric addition of dialkylmagnesium compounds to aldehydes. AU the alcohols have the (R)-configuration. Toluene was found to be a superior solvent for this reaction lower temperatures increasfe optical yields. Only one example of use of an aliphatic aldehyde was reported only a low optical yield was obtained. ... 

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