Asymmetric oxygen coordination sphere

Asymmetric hydrogenation (Section 9.3) of C=C, C=0, and C=N bonds is widely employed with numerous catalysts. The example shown in Eq. 14.20 uses a Noyori catalyst that is believed to operate by an outer-sphere mechanism of Section 9.3 with transfer of H from the metal to carbonyl carbon and H+ from the amino hgand to the carbonyl oxygen, the carbonyl substrate not being directly coordinated to the metal. 

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