Asymmetric Organocatalysis Introducing a Thiourea Catalyst for the Petasis Reaction

3 Asymmetric Organocatalysis Introducing a Thiourea Catalyst for the Petasis Reaction 

Due to the technological importance of this reaction, its study over a quarter of century has resulted in some fascinating improvements. For instance, the quantity of the catalyst was lowered from 200 to 3 mol%, while enantioselectivity was enhanced from 71% in MeCN at 80°C, to 88% in DMF [9, 10]. 

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