Asymmetric chiral catalyst-driven

This topic has been reviewed by Malacria, Pelhssier, and their coworkers [5] in two excellent articles. The present section deals with asymmetric radical domino processes covering chiral auxihary-directed and chiral catalyst-driven processes mainly developed in the past several years. However, chiral reagentradical domino reactions have rarely been reported. 

Chiral Catalyst-Driven Asymmetric Radical Domino Processes... 

Asymmetric hydrogenation is perhaps the most efficient, cost-effective, and environmentally friendly method for constructing chiral compounds. Driven by the demand for enantiomerically pure pharmaceuticals and fine chemicals, new and efficient catalysts have been and continue to be discovered. With the use of transition metal complexes with chiral ligands, both the efficiency and effectiveness of newly sjmthesized ligands are frequently tested in asymmetric hydrogenation reactions. The... 

Asymmetric transfer hydrogenation (ATH) reactions of 2-substituted a-alko gr-p-ketophosphonates (602) driven by dynamic kinetic resolution, afforded the corresponding 2-substituted a-alko gr-p-hydroxyphos-phonates (603) with excellent levels of diastereo- and enantioselectivity (Scheme 175). The reactions have been promoted by using chiral ruthenium catalyst (604) and a 0.2 1 mixture of formic acid and triethylamine as the hydrogen source and solvent. ... 

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