Asymmetric Addition to Imine Derivatives

The asymmetric addition of trimethylsilylcyanide to aldehyde was catalyzed by a chirally modified Lewis acid. Polymer-supported chiral bis(oxazoline)s (46, 47) were prepared and used as ligands of ytterbium chloride ]30]. The polymeric hgands exhibited as high a reactivity in the asymmetric silylcyanation as did their 

Heterogeneous Enantioselective Catalysis Using Organic Polymeric Supports 

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Examples in Table 3 highlight 1,2-asymmetric additions to imine derivatives. Tanaka [25] reported the addition of alkyl Grignard reagents to the isoquinolines to yield a single enantiomer (see Table 3, entry 1). 

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