Asthma, myosin light chain Kinase

Pj-selective agonists such as prenalterol (Figure 10.5) or dobutamine are used to stimulate heart contractility and heart rate in patients that exhibit too low blood pressure. P2-Selective agents such as terbutaline find application for relaxation and dilatation of the bronchi in the treatment of asthma or chronic obstmctive lung disease, and in the suppression of premature labour. The mechanism of P-receptor-induced relaxation of smooth muscle - cAMP-mediated phosphorylation and inhibition of myosin light chain kinase - has been described before. 

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