Asthma, hay Fever and anaphylaxis

Sf A MDGENS histamine leucotrlenes (LTC4. LTD4) prosta lanelins CFGP2) [Pg.28]

MUSCARINIC ANTA 30N16T ipratropium LTD, antagonist montelukast [Pg.28]

Acute severe attacks nf asthma (status asihmulicus) that are not controlled hy the patient s usual drugs are potentially fatal and must be dealt with as an emergency, requiring hospital admission. [Pg.28]

Mast cells contain the body stores of histamine and occur in almost all tissues. Within the ma.st cells, histamine is bound with heparin in cytoplasmic gnmules. Hi.siatnine release normally involves an influx of Ca- ionstmd, because iJie permeability of the cel I membrane toCa ions is reduced when intraeellularcAMF levels are raised, drugs that stimulate cAMP synthesis (pyadrenoeeptor agonists) reduce histamine relea.se. [Pg.29]

Ipratropium is a muscarinic amagoni.st and a modcralety effective hronehodilator, presumably because it reduces reflex vagal broncho-constriction that results from hisiatnine. stimulation of sensory (irritant) rece))tors in the airways, ipratropium given by inhalation rarely causes atropine-1 ike side-effects. [Pg.29]

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