Astex library

Examples of both approaches towards library design have been described in the literature [35, 47-50], and commercially available fragment libraries are also now available as described by Bauman et al. [46]. We next review the approach taken towards fragment-library generation at Astex. 

Astex s fragment libraries have continued to evolve, and have now been consolidated to give the current CFS. An important part of this has been a thorough... 

Example 2. The concept of leadlikeness [32, 55, 56] and its application in developing leadlike libraries [55, 57, 58] have been extensively discussed. The reduction of the leadlike concept into practice at Astex [59] resulted in a proposal for fragment libraries in lead discovery called the Rule of Three ... 

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