Association of drug molecules

Considering the ionic micelle MP+ to be formed by association of n drug ions, D+, and (n — p) firmly bound counter ions, X,  

The equilibrium constant for micelle formation assuming ideality is given by 

The standard free energy of micellization per mole of monomeric drug is given 

Assuming the monomeric drug concentration Xg, in the presence of micelles, to be equal to the c.m.c., Eq. (13.20) may be written in a simple form, 

Later studies on other drugs with non-micellar association patterns showed that the apparent c.m.c. detected by surface tension techniques arose because of the very limited change of monomer concentration with total solution concentration at high concentrations. 

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Several other examples may be quoted to illustrate the association of drug molecules producing either micelles or other association structures. For more detail the reader should refer to the text by Attwood and Florence [14]. 

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See also in sourсe #XX -- [ ]

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