Assessing Validity and Scientific Soundness of Q SAR

It should be emphasized that, for mechanistically complex endpoints such as carcinogenicity, a sound mechanistic basis should be strongly preferred if high confidence is needed. 

An in-depth discussion of the criteria needed to assess the scientific soundness of (Q)SAR was the focus of an International Life Science Institute (ILSI) and 

Environmental Protection Agency (ERA) workgroup that dealt with issues related to (a) selection of proper endpoint or characteristics for (Q)SAR analysis, 

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