Aspergillus artemisinin

Aspergillus nigen shakers during 14 days. Residual artemisinin after 5p-Hydroxyartemisinin ... 

Studies on the microbial transformation of artemisitene 27 by Aspergillus niger yielded 11- f-artemisinin 88a, 9/3-hydroxydeoxy-1 l-< /)/-artemisinin 89, and 9/3-hydroxy-l l-< /)/-artemisinin 88b. These metabolites were characterized on the basis of their spectral data <1999P257>. When artemisinin 9a was transformed hy Mucorpolymorphosporus or A. niger, five products were identified as 9/3-hydroxyartemisinin 90, 3/3-hydroxyartemisinin 91, deoxyartemisinin 75b, 3/3-hydroxydeoxyartemisinin 75a, and la-hydroxydeoxyartemisinin 92 <2002JNP1693>. 

FIGURE 20.88 Biotransformation of artemisinin (283) by Aspergillus niger, Nocardia corallina, and... 

Zhan et al. (2002) reported that incubation of artemisinin (283) with Cunninghamella echinulata and Aspergillus niger for 4 days at 28°C resulted in the isolation of two metabolites, 10 i-hydroxyar-temisinin (287a) and 3a-hydroxydeoxyartemisinin (285), respectively. 

---