Aspartate climbing fibers

Vollenweider FX, Cuenod M, Do KQ (1990) Effect of climbing fiber deprivation on release of endogenous aspartate, glutamate, and homocysteate in slices of rat cerebellar hemispheres and vermis. J Neurochem 54 1533-1540. 

Wiklund L, Toggenburger G, Cuenod M (1982) Aspartate possible neurotransmitter in cerebellar climbing fibers. Science 276 78-80. 

Several observations have led to the assumption that L-aspartate is the principal neurotransmitter of climbing fibers. (1) Destruction of the inferior olive in the rat with... 

Aspartate is closely related metabolically and chemically to glutamate. In many respects it is difficult to differentiate between aspartate and glutamate as neurotransmitter candidates (Fonnum, 1984). There are, however, some fibers and terminals in which aspartate is regarded as a stronger transmitter candidate than glutamate. These include the cerebellar climbing fibers (Wiklund et al., 1982), hippocampal commissural fibers (Nadler et al., 1978), olfactory tract (Collins and Probett, 1981), cochlear nucleus afferents (Wenthold, 1979), and spinal cord intemeurons (Davidoff et al., 1967)... 

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