Asialoglycoproteins catabolism

Harford, J., Klausner, R.D., and Ashwell, G. Inhibition of the endocytic pathway for asialoglycoprotein catabolism. Biol Cell (1984)5/, 173-179. 

AAG is synthesized primarily by the hepatic parenchymal cells, but granulocytes and monocytes may also contribute to plasma levels in sepsis. Catabolism is believed to be primarily by removal of desialylated AAG by hepatic asialoglycoprotein receptors. The plasma half-life of intact AAG is 3 days, whereas that of the desialylated protein is only a few minutes. 

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