Aseptic packaging technique

The blow/fill/seal process is a complete packaging technique that integrates the extrusion or IBM and container filling steps. This can provide for aseptic filling of the hot as-blown container and is used for pharmaceutical, food, and cosmetic products. The process employs a two-part mold in which the container body mold cavity blocks are separate from the neck-forming members. 

Matsumoto et al. (3). Container and sterilization technique in aseptic packaging of foods in plastic or paper-based containers were fully discussed by Toledo (4) and Ito et al. (5). 

As a result of extensive development and testing by thermoprocessing or aseptic techniques, the use of flexible, laminated aluminum pouches and formed aluminum containers for shelf-stable foods is nearing commercial reality. The increasing use of aluminum for food packaging has been made possible by successfully combining it with specialized plastics, papers, adhesives, and coatings. In many applications, aesthetic as well as protective characteristics are also provided. 

A separately packaged sterile diluent and sterile dropper assembly is provided with the sterile powder and requires aseptic technique to reconstitute. The pharmacist should only use the diluent supplied by the manufacturer since it has been developed to maintain the optimum potency and preservation of the reconstituted solution. The storage conditions and expiration dating for the final solution should be emphasized to the patient. 

Carefully open filter package and, using aseptic techniques, place sterile filter membrane (grid side up) onto the sterile filter housing, taking care not to create wrinkles in membrane during closure. 

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