Aseptic filling processing capability

Broth fills should be a major part of the operational qualification of a new BFS machine to demonstrate aseptic processing capability prior to product manufacture (typically three successful consecutive broth fills are required) and should be carried out at defined intervals thereafter. 

Isolators are now used in industrial scale aseptic processing for both formulation and filling. Fig. 5 shows an example of a rigid interconnected network of isolators providing a complete component handling and aseptic filling capability in an integrated line. The internal... 

In food processing, it is a process condition that renders a processed food product essentially free of microorganisms capable of growing in the food in un-refrigerated distribution and storage conditions. The aseptic food packaging include film pouches and presterilized molded containers that are filled with aseptic foods, then hermetically sealed in a commercially sterile atmosphere. 

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